Predictors of HAND | HIV Management Guidelines

Studies suggest predictors of HAND include: past history of AIDS-defining central nervous system (CNS) disease,^{^[18]} other CNS disease,^{^[19]}low T cell nadir,^{^[20]} longer duration of HIV infection,^{^[21]}drug and alcohol use,^{^[22]} and hepatitis C infection.^{^[23].}Additionally, the risk of HAND increases as the CD4+ counts decline below 350cells/uL and with higher plasma viral load.^{^[24]}