Clinical presentation | HIV Management Guidelines

Approximately 10-20% of patients with HIV infection and cryptococcal infection have cutaneous lesions, which usually represent haematogenous spread, and it is a marker of disseminated infection.^[83], ^[84] These lesions can have varying morphologies including: umbilicated papules and nodules similar to molluscum, erythematous papules, nodules, pustules, ulcers, herpetiform vesicles and inﬁltrated plaques or subcutaneous swelling. The diﬀerential is broad and therefore the lesions should be biopsied and cultured.^[85]