Clinical presentation

Approximately   10-20%   of   patients   with   HIV   infection   and cryptococcal infection have cutaneous lesions, which usually represent   haematogenous   spread, and it is a marker of disseminated infection.[83][84]   These   lesions   can   have varying   morphologies   including:   umbilicated   papules   and nodules similar to molluscum, erythematous papules, nodules, pustules, ulcers, herpetiform vesicles and infiltrated plaques or subcutaneous swelling. The differential is broad and therefore the lesions should be biopsied and cultured.[85]